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Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist FDA-approved for type 2 diabetes and chronic weight management

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Despite these limitations, the consistent signal of fatigue reduction makes ALCAR a cornerstone of metabolic support protocols for ME/CFS, often used alongside other amino acids as detailed in our guide, Can Free-Form Amino Acids Support Energy and Brain Fog in Long COVID and ME/CFS

This suggests that semaglutide maintains metabolic activity (or prevents compensatory downregulation of EE) despite weight loss, thereby aiding in prolonged weight loss or maintenance